Portfolio intelligence
Grounded in 12 structured asset records — outcome history, rollups, and shared mechanisms. No prediction, no scores.
Outcome distribution
5
Clinical entry
5
Active
1
Licensed
1
Dormant
By disease area
| Group | Assets | Advanced | Stalled |
|---|---|---|---|
| Neurodegeneration | 6 | 2 | 1 |
| Neuromuscular | 2 | 2 | 0 |
| Cholestatic liver disease | 1 | 0 | 0 |
| Epilepsy | 1 | 1 | 0 |
| Neurodevelopmental | 1 | 0 | 0 |
| Pulmonary | 1 | 1 | 0 |
By modality
| Group | Assets | Advanced | Stalled |
|---|---|---|---|
| Gene therapy (AAV) | 4 | 1 | 1 |
| Small molecule | 4 | 2 | 0 |
| Antisense oligonucleotide | 3 | 2 | 0 |
| Monoclonal antibody | 1 | 1 | 0 |
Shared mechanisms
targets across ≥2 programsPublic competitive-landscape depth (every program on a target, globally) is where [signal.] would call out to a public-evidence engine — here it stays within the portfolio.
Maintenance gaps
missing updates vs. registry — deterministic- HTT-Lowering ASO for Huntington DiseaseLast snapshot 715d ago (stale)Registered trial(s) without a recent progress updateMarked active but progress is stale
- JAG1 Modulator for Alagille SyndromeLast snapshot 350d ago (stale)Registered trial(s) without a recent progress updateMarked active but progress is stale
- CFTR Corrector Triple CombinationLast snapshot 623d ago (stale)Registered trial(s) without a recent progress update
- Microdystrophin Gene Transfer (DMD)Last snapshot 441d ago (stale)Registered trial(s) without a recent progress update
- SMN2 Splicing Enhancer (Oral)Last snapshot 623d ago (stale)Registered trial(s) without a recent progress update
- Anti-Amyloid Monoclonal (Early AD)No progress snapshot recorded
- FXN Frataxin Restoration ProgramNo progress snapshot recorded
- GBA1 Gene Therapy for Parkinson DiseaseNo progress snapshot recorded
- MECP2 Dosage-Controlled Gene TherapyNo progress snapshot recorded
- SCN1A Upregulation for Dravet SyndromeNo progress snapshot recorded
- SOD1 Antisense OligonucleotideLast snapshot 441d ago (stale)
- SOD1 Stabilizer (Small Molecule)No progress snapshot recorded
AI pattern brief
flag off · defaultPhase 7Flag-gated, default off. With SIGNAL_LLM_ENABLED=1 (+ a provider key), generates a grounded summary of portfolio patterns from the aggregate counts above — validated for no probability-of-success or buy/sell language.